Synthesis of symmetrical pseudopeptides as potential inhibitors of the human immunodeficiency virus-1 protease

M Langlois, D Quintard, C Abalain

Index: Langlois; Quintard; Abalain European Journal of Medicinal Chemistry, 1994 , vol. 29, # 9 p. 639 - 647

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Citation Number: 19

Abstract

Abstract It is demonstrated that HIV-1 protease is essential for the assembly and infectivity of the acquired immunodeficiency syndrome (AIDS) virus. This protease is an aspartyl protease with a 2-fold symmetry axis. Potential inhibitors were synthesized and consisted of a spacer linking 2 peptidic chains. They had to satisfy the following constraints: a C 2 symmetry axis, a backbone similar to the peptidic substrates, and side-chains filling the ...