Journal of medicinal chemistry

. beta.-Adrenoceptor studies. 1. In vitro. beta.-adrenergic blocking, antiarrhythmic, and local anesthetic activities of a new series of aromatic bis (2-hydroxy-3- …

J Zaagsma, WT Nauta

Index: Zaagsma,J.; Nauta,W.T. Journal of Medicinal Chemistry, 1974 , vol. 17, # 5 p. 507 - 513

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Citation Number: 25

Abstract

A series of bis (2-hydroxy-3-isopropylaminopropyl) ethers of dihydroxyarenes (1-10) was synthesized and investigated in vitro for (1)@-adrenergic blocking activity,(2) antagonism of ouabain-induced arrhythmias,(3) inotropic and chronotropic effects, and (4) local anesthetic activity. For comparison, the monoethers l-isopropylamino-3-(1-naphthoxy)-2-propanol (propranolol) and l-isopropylamino-3-phenoxy-2-propanol(11) were also studied. ...

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