Synthesis and transdermal permeation-enhancing activity of carbonate and carbamate analogs of Transkarbam 12

…, K Vávrová, M Šíma, J Klimentová, A Hrabálek

Index: Holas, Tomas; Vavrova, Katerina; Sima, Martin; Klimentova, Jana; Hrabalek, Alexandr Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 23 p. 7671 - 7680

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Citation Number: 19

Abstract

Transkarbam 12 (5-(dodecyloxycarbonyl) pentylammonium-5-(dodecyloxycarbonyl) pentylcarbamate, T12) is a highly effective skin permeation enhancer. In this study, ester groups in the molecule of T12 were replaced by carbonate and carbamate ones, respectively. The in vitro permeation-enhancing activities were evaluated using porcine skin and compared with those of T12 and previously prepared series of amide, ketone, and ...

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