Direct preparation of primary amides by reaction of carboxylic acids and ammonia in alcohols using DMT-MM

T Mizuhara, K Hioki, M Yamada, H Sasaki, D Morisaki…

Index: Mizuhara, Tsukasa; Hioki, Kazuhito; Yamada, Megumi; Sasaki, Hideaki; Morisaki, Daiki; Kunishima, Munetaka Chemistry Letters, 2008 , vol. 37, # 12 p. 1191 - 1192

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Citation Number: 5

Abstract

A simple and mild method for the direct conversion of carboxylic acids to primary amides has been developed by using 4-(4, 6-dimethoxy-1, 3, 5-triazin-2-yl)-4-methylmorpholinium chloride (DMT-MM). The reaction proceeds by adding DMT-MM to a mixture of carboxylic acids and an ammonia source in methanol, 2-propanol, or THF without any additives. The present method is quite practical in that aqueous ammonia or ammonium chloride/ ...

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