First asymmetric synthesis of Silodosin through catalytic hydrogenation by using Ir-SIPHOX catalysts

PC Yan, XY Zhang, XW Hu, B Zhang, XD Zhang…

Index: Tetrahedron Letters, , vol. 54, # 11 p. 1449 - 1451

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Citation Number: 2

Abstract

... Tetrahedron Letters. Volume 54, Issue 11, 13 March 2013, Pages 1449–1451. ... 11 and 12 The reaction was initially performed at a substrate to catalyst mole ratio (S/C) of 400 in MeOH under 8 atm of H 2 at 70 °C for 24 h (Table 1). With catalyst (R a ,R)-1a, the hydrogenation ...