New fluorinated pyrrolidine and azetidine amides as dipeptidyl peptidase IV inhibitors

B Hulin, S Cabral, MG Lopaze…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 21 p. 4770 - 4773

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Citation Number: 37

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... In this letter, we report an improved preparation of 3,3,4,4-tetrafluoropyrrolidine, a synthesis of the novel building block cis-3,4-difluoropyrrolidine and the unexpected strong DPPIV inhibition of the corresponding cyclohexylglycine ...