Practical synthesis of (3S, 4S)-3-methoxy-4-methylaminopyrrolidine

Y Tsuzuki, K Chiba, K Mizuno, K Tomita…

Index: Tetrahedron Asymmetry, , vol. 12, # 21 p. 2989 - 2997

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Citation Number: 27

Abstract

... Tetrahedron: Asymmetry. Volume 12, Issue 21, 26 November 2001, Pages 2989–2997. ... Cleavage of the amide of 12 with 20% NaOH in EtOH at 50°C smoothly afforded (S,S)-4 in 93% yield and protection of (S,S)-4 with Boc 2 O afforded 13 in 98% yield. ...