Simple Methodology for the Preparation of Amino Alcohols from Amino Acid Esters Using NaBH4–Methanol in THF

RSB Gonçalves, AC Pinheiro, ET Da Silva…

Index: Goncalves; Pinheiro; Da Silva; Da Costa; Kaiser; De Souza Synthetic Communications, 2011 , vol. 41, # 9 p. 1276 - 1281

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Citation Number: 8

Abstract

Abstract Amino alcohols constitute a very useful and versatile class of organic compounds, with important applications in synthetic and medicinal chemistry. However, in most of the procedures described in the literature for the obtainment of these compounds, considerable limitations can be found, such as drastic conditions, long time reactions, poor yields, and purification problems. The present article describes a methodology that gives amino ...