Chlorodifluoromethyl aryl ketones and sulfones as difluorocarbene reagents: The substituent effect
F Wang, L Zhang, J Zheng, J Hu
Index: Wang, Fei; Zhang, Laijun; Zheng, Ji; Hu, Jinbo Journal of Fluorine Chemistry, 2011 , vol. 132, # 8 p. 521 - 528
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Citation Number: 17
Abstract
Abstract We have investigated the different chlorodifluoromethyl aryl ketones 1a–1g and sulfones 2a–2h as difluorocarbene reagents for O-and N-difluoromethylations. It was found that the sulfone reagents 2 were generally more efficient in difluoromethylation than the ketone reagents 1. Furthermore, while the different substituents on ketone reagents 1 did not show a remarkable impact on the difluoromethylation reaction, the substituent effect on the ...
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