α-Bromoacid Amides and Ureas as Anticonvulsants

SR Safir, H Dalalian, W Fanshawe, K Cyr…

Index: Safir et al. Journal of the American Chemical Society, 1955 , vol. 77, p. 4840,4842

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Citation Number: 11

Abstract

-1lthough a-bromoamides and ureas have for many years been used in medicine as sedatives and hypnotics, no systematic survey of this class of drugs for anticonvulsant potentiality appears to have been made.'The finding that neuronal (I) and carbromal (11) exhibited a high degree of protection against metrazole-induced seizures in rats gave impetus to the hope that a drug useful in petit mal epilepsy might be found in the class of ...