1H-Pyrazole-1-carboxamidine hydrochloride an attractive reagent for guanylation of amines and its application to peptide synthesis

MS Bernatowicz, Y Wu…

Index: Bernatowicz, Michael S.; Wu, Youling; Matsueda, Gary R. Journal of Organic Chemistry, 1992 , vol. 57, # 8 p. 2497 - 2502

Full Text: HTML

Citation Number: 301

Abstract

Introduction The possibility of preparing arginine-containing peptides by guanylation of the 6- amino groups of the appropriate ornithine-containing precursors has long been recognized. Such a strategy is attractive for its potential to eliminate the many problems associated with the use of conventionally protected arginine starting materials in peptide synthesis. 2 It is also attractive because it allows for the

Related Articles:

Conformations, conformational preferences, and conformational exchange of N′-substituted N-acylguanidines: intermolecular interactions hold the key

[Kleinmaier, Roland; Keller, Max; Igel, Patrick; Buschauer, Armin; Gschwind, Ruth M. Journal of the American Chemical Society, 2010 , vol. 132, # 32 p. 11223 - 11233]

Solvent-free synthesis of azole carboximidamides

[Zahariev, Sotir; Guarnaccia, Corrado; Lamba, Doriano; Cemazar, Masa; Pongor, Sandor Tetrahedron Letters, 2004 , vol. 45, # 51 p. 9423 - 9426]

Guanidine− Acylguanidine Bioisosteric Approach in the Design of Radioligands: Synthesis of a Tritium-Labeled N G-Propionylargininamide ([3H]-UR-MK114) as a …

[Journal of Medicinal Chemistry, , vol. 51, # 24 p. 8168 - 8172]

More Articles...