Ultrasound improves the synthesis of 5-hydroxymethyl-2-mercapto-1-benzylimidazole as a base compound of some pharmaceutical products

MH Entezari, A Asghari

Index: Entezari, Mohammad H.; Asghari, Azam European Journal of Medicinal Chemistry, 2008 , vol. 43, # 12 p. 2835 - 2839

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Abstract

Application of ultrasound in synthesis appears to be a promising alternative for high-value chemicals and pharmaceuticals. This work describes the results of investigations carried out towards the synthesis of 5-hydroxymethyl-2-mercapto-1-benzylimidazole (HMMBI) in the presence of ultrasound (sono-synthetic) and in the absence of ultrasound (control method). Instead of mixing for long time in control method, the mixture was sonicated indirectly with ...