Discovery of a 1, 5-dihydrobenzo [b][1, 4] diazepine-2, 4-dione series of inhibitors of HIV-1 capsid assembly

LD Fader, R Bethell, P Bonneau, M Bös…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 1 p. 398 - 404

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Citation Number: 48

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... In doing so, we were particularly concerned with the inherent electrophilicity of the enamine moiety, which could lead to problems of chemical instability and even to conjugation to biomolecules in vivo. ...

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