Amino acids

A preparation of N-Fmoc-N-methyl-α-amino acids and N-nosyl-N-methyl-α-amino acids

ML Di Gioia, A Leggio, A Liguori, F Perri, C Siciliano…

Index: Di Gioia, Maria Luisa; Leggio, Antonella; Liguori, Angelo; Perri, Francesca; Siciliano, Carlo; Viscomi, Maria Caterina Amino Acids, 2010 , vol. 38, # 1 p. 133 - 143

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Citation Number: 13

Abstract

Abstract A convenient route for the synthesis of lipophilic N-Fmoc-N-methyl-α-amino acids and N-nosyl-N-methyl-α-amino acids, interesting building blocks to be used for the preparation of N-methylated peptides, is presented. Both nosyl-and Fmoc-protected monomers are accessible, so these compounds can be used in solution as well as in solid phase peptide synthesis. The methodology is based on the use of benzhydryl group to ...

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