Antitumor agents 155. Synthesis and biological evaluation of 3', 6, 7-substituted 2-phenyl-4-quinolones as antimicrotubule agents

L Li, HK Wang, SC Kuo, TS Wu, A Mauger…

Index: Li, Leping; Wang, Hui-Kang; Kuo, Sheng-Chu; Wu, Tian-Shung; Mauger, Anthony; et al. Journal of Medicinal Chemistry, 1994 , vol. 37, # 20 p. 3400 - 3407

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Citation Number: 144

Abstract

A series of 3', 6, 7-substituted 2-phenyl-4-quinolones were designed and synthesized as antimitotic antitumor agents. All compounds showed cytotoxic effects (log GI50 I-4.0; log drug molar concentration required to cause 50% inhibition) against the growth of a variety of human tumor cell lines, including those derived from solid tumors such as non-small cell lung, colon, central nervous system, ovary, prostate, and breast cancers, when evaluated ...