Substituted 2-hydroxy-1, 2-dihydropyrrol-3-ones: Fluorescent markers pertaining to oxidative stress and aging

P Chen, D Wiesler, J Chmelík…

Index: Chen, Peng; Wiesler, Donald; Chmelik, Josef; Novotny, Milos Chemical Research in Toxicology, 1996 , vol. 9, # 6 p. 970 - 979

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Citation Number: 23

Abstract

Previous observations that the aging process correlates with occurrence of certain fluorescent biological pigments have led to numerous efforts in elucidating the chemical nature of the fluorophores generated through reactions of primary amines and various products of lipid peroxidation. In this study, model reactions of saturated aldehydes with aliphatic amines in the presence of peroxides were found to generate structurally unusual ...

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