An efficient kinetic resolution of racemic Betti base based on an enantioselective N, O-deketalization

Y Dong, R Li, J Lu, X Xu, X Wang…

Index: Wang, Xinyan; Dong, Yanmei; Sun, Jianwei; Xu, Xuenong; Li, Rui; Hu, Yuefei Journal of Organic Chemistry, 2005 , vol. 70, # 5 p. 1897 - 1900

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Citation Number: 51

Abstract

An efficient kinetic resolution of racemic Betti base with l-(+)-tartaric acid in acetone was developed based on a novel enantioselective N, O-deketalization, by which the enantiopure R-and S-enantiomers of Betti base were obtained as the corresponding N, O-ketal compound and salt with l-(+)-tartaric acid, respectively, in excellent yields with a practically foolproof operation.