Synthesis and anticonvulsant activity of 8-alkoxy-5, 6-dihydro-4H-benzo [f][1, 2, 4] triazolo [4, 3-a] azepine derivatives

WB Zhang, RB Han, W Zhang, RS Jiang…

Index: Zhang, Wen-Bin; Han, Rong-Bi; Zhang, Wei; Jiang, Ri-Shan; Piao, Feng-Yu Medicinal Chemistry Research, 2012 , vol. 21, # 9 p. 2587 - 2594

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Abstract

Abstract A novel series of 8-alkoxy-5, 6-dihydro-4H-benzo [f][1, 2, 4] triazolo [4, 3-a] azepine derivatives were synthesized and characterized by IR, 1 H NMR, 13 C NMR, mass spectroscopy, and elemental analysis. The newly synthesized compounds were screened for their anticonvulsant activities by the maximal electroshock (MES) test and subcutaneous pentylenetetrazol (scPTZ) test, and their neurotoxic effects were determined by the rotarod ...

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