Antiallergy agents. 1. Substituted 1, 8-naphthyridin-2 (1H)-ones as inhibitors of SRS-A release

…, JJ Kaminski, WC Tom, JF Lee, SC Wong…

Index: Sherlock, Margaret H.; Kaminski, James J.; Tom, Wing C.; Lee, Joe F.; Wong, Shing-Chun; et al. Journal of Medicinal Chemistry, 1988 , vol. 31, # 11 p. 2108 - 2121

Full Text: HTML

Citation Number: 68

Abstract

Scheme I). The required nicotinic acids and esters described in Table I, and the substituted amines described in the experimental section were either commercially available or their method of preparation has been described previo~ sly.~*-~~ The substituted pyridines (3) and congeners described in Table I1 were prepared by the procedures described by Kermack and Weatherhead24 or Nantka-N amir~ ky,~~ respectively. Following the ...