Tetrahedron Letters

Concise total syntheses of Marinoquinolines A–C

L Ni, Z Li, F Wu, J Xu, X Wu, L Kong, H Yao

Index: Ni, Lijun; Li, Ziyuan; Wu, Fan; Xu, Jinyi; Wu, Xiaoming; Kong, Lingyi; Yao, Hequan Tetrahedron Letters, 2012 , vol. 53, # 10 p. 1271 - 1274

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Citation Number: 16

Abstract

The first concise total syntheses of pyrroloquinoline natural products, Marinoquinolines A–C, have been achieved in six linear steps from commercially available starting materials. The key steps were a reaction between (p-tolylsulfonyl) methylisocyanide (TosMIC) and α, β- unsaturated ester under basic condition to prepare the pyrrole moiety and Morgen-Walls reaction to construct quinoline ring.

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