Molecules

Functionalized 4-hydroxy coumarins: novel synthesis, crystal structure and DFT calculations

…, A Afantitis, G Athanasellis, O Igglessi-Markopoulou…

Index: Stefanou, Valentina; Matiadis, Dimitris; Melagraki, Georgia; Afantitis, Antreas; Athanasellis, Giorgos; Igglessi-Markopoulou, Olga; McKee, Vickie; Markopoulos, John Molecules, 2011 , vol. 16, # 1 p. 384 - 402

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Citation Number: 17

Abstract

Abstract A novel short-step methodology for the synthesis in good yields of functionalized coumarins has been developed starting from an activated precursor, the N- hydroxysuccinimide ester of O-acetylsalicylic acid. The procedure is based on a tandem C- acylation-cyclization process under mild reaction conditions. The structure of 3- methoxycarbonyl-4-hydroxy coumarin has been established by X-ray diffraction analysis ...

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