An Improved and Scalable Process for the Synthesis of 5-Azacytidine: An Antineoplastic Drug

…, R Bandichhor, M Kagga, P Cherukupally

Index: Vujjini, Satish Kumar; Varanasi, Ganesh; Arevelli, Srinivas; Kandala, Sreenatha Charyulu; Tirumalaraju, Satyanarayana Raju; Bandichhor, Rakeshwar; Kagga, Mukkanti; Cherukupally, Praveen Organic Process Research and Development, 2013 , vol. 17, # 2 p. 303 - 306

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Citation Number: 4

Abstract

An improved, practical, and scalable process for the manufacture of antineoplastic drug, 5- azacytidine (1), is described. A thorough understanding of the reaction parameters and stability of the reaction intermediates led us to the development of a robust process. The challenges in the isolation and systematic approach used to streamline the process into a very robust and practical manufacturing process are described.