2-Amino-5-aryl-pyridines as selective CB 2 agonists: Synthesis and investigation of structure–activity relationships

RJ Gleave, PJ Beswick, AJ Brown, GMP Giblin…

Index: Bioorganic and Medicinal Chemistry Letters, , vol. 19, # 23 p. 6578 - 6581

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Citation Number: 10

Abstract

... Bioorganic & Medicinal Chemistry Letters. ... Following the analysis of results from a high-throughput screen (HTS), initial exploratory chemistry identified pyridine 1 as a low molecular weight and chemically tractable hit which showed a promising level of CB 2 potency and ...