1??Alkyl??and Azeto [1, 2??a][1, 5] benzodiazepine Derivatives in the Reaction of o??Phenylenediamine with 3??(Dimethylamino) propiophenones

…, J Quiroga, A Salcedo, H Kolshorn…

Index: Insuasty, Braulio; Abonia, Rodrigo; Quiroga, Jairo; Salcedo, Angela; Kolshorn, Heinz; Meier, Herbert European Journal of Organic Chemistry, 2000 , # 10 p. 1973 - 1976

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Citation Number: 4

Abstract

Abstract The reaction of o-phenylenediamine (4) with one, two or three equivalents of p- substituted 3-dimethylaminopropiophenone hydrochlorides 5a− e was studied. 4-Aryl-2, 3- dihydro-1H-1, 5-benzodiazepine derivatives 6a− e were obtained in good yields, along with the 1: 2-adducts 7c− e and the unexpected 1: 3-adducts rac-8c− e. The type of adduct formed is determined by the molar ratio of the reactants 4 and 5 and by the nature of the ...