A facile stereospecific synthesis of. alpha.-fluoro. beta.-amino acids

L Somekh, A Shanzer

Index: Somekh, Lila; Shanzer, Abraham Journal of the American Chemical Society, 1982 , vol. 104, # 21 p. 5836 - 5837

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Citation Number: 56

Abstract

Fluorinated analogues of bioactive compounds are finding increasing use as chemical probes for biomedical research, as radiographic tools, and as therapeutic agents of increasing lipid permeability and metabolic stability.'Although@-amino acids occur fairly widely in nature,* only a few of them have been synthesized so far. a-Fluoro-@-alanine (a metabolite of the antitumor drug 5-fluorouracil) has been prepared in several steps from ...