Synthesis and dopaminergic activity of some halogenated mono-and dihydroxylated 2-aminotetralins

J Weinstock, D Gaitanopoulos, HJ Oh…

Index: Weinstock, Joseph; Gaitanopoulos, Dimitri E.; Oh, Hye-Ja; Pfeiffer, Francis R.; Karash, Carole B.; et al. Journal of Medicinal Chemistry, 1986 , vol. 29, # 9 p. 1615 - 1627

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Citation Number: 28

Abstract

In a series of 7, 8-dihydroxy-l-phenyltetrahydro-3-benzazepine dopamine receptor agonists introduction of a chloro or fluoro substituent into the 6-position increases dopaminergic potency. Also, in this series replacement of the 7-hydroxyl group with a halogen results in inversion of activity from dopamine receptor agonist to antagonist. The present study was aimed at exploring the possibility that the structure-activity observations in the 3- ...