Dopamine agonists related to 3-allyl-6-chloro-2, 3, 4, 5-tetrahydro-1-(4-hydroxyphenyl)-1H-3-benzazepine-7, 8-diol, 6-position modifications

…, G Gallagher Jr, M Brenner, JW Wilson…

Index: Ross, Stephen T.; Franz, Robert G.; Gallagher, Gregory; Brenner, Martin; Wilson, James W.; et al. Journal of Medicinal Chemistry, 1987 , vol. 30, # 1 p. 35 - 40

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Citation Number: 7

Abstract

(I Key:(a) H2S04, HOAc, HzO, reflux (basic hydrolysis was used in the case of 6);(b) S0Cl2;(c) H2NCH2CHOHCBH4-4-OCH3, base;(d) BH3-THF, CH30H, HCl, base;(e) H2SO4, CF3C02H, reflux [H2S04 was replaced by CF3S03H in the cases of 7 and 11 (step e)];(f) BrCH2CH= CH2, K2C03;(9) BBr3, CH2C12, CH30H, base, CHSSO3H (13 was isolated as its HBr salt).* lo is the corresponding phenylacetic acid (commercially available). tiveness, ...