Tetrahedron

Fluoroform: an efficient precursor for the trifluoromethylation of aldehydes

B Folléas, I Marek, JF Normant, L Saint-Jalmes

Index: Folleas, Benoit; Marek, Ilan; Normant, Jean-F.; Saint-Jalmes, Laurent Tetrahedron, 2000 , vol. 56, # 2 p. 275 - 283

Full Text: HTML

Citation Number: 86

Abstract

Classical methods for the synthesis of trifluoromethylated aromatics come from the beginning of this century. Indeed, Swarts discovered that antimony trifluoride could be used to convert benzotrichloride into benzotrifluoride. 6 Later, it was found that hydrogen fluoride could also fluorinate benzotrichloride to yield the trifluoride. 7 These methods are still used today, but have a number of disadvantages relating to the harsh conditions they impose and their toxicity. These facts have led to the ...

Related Articles:

Discovery of potent, selective, orally active benzoxazepine-based Orexin-2 receptor antagonists

[Fujimoto, Tatsuhiko; Kunitomo, Jun; Tomata, Yoshihide; Marui, Shogo; Nishiyama, Keiji; Nakashima, Masato; Yoshikubo, Shin-Ichi; Hirai, Keisuke; Hirozane, Mariko Bioorganic and Medicinal Chemistry Letters, 2011 , vol. 21, # 21 p. 6414 - 6416]

Catalytic decarboxylative fluorination for the synthesis of tri-and difluoromethyl arenes

[Mizuta, Satoshi; Stenhagen, Ida S.R.; O'Duill, Miriam; Wolstenhulme, Jamie; Kirjavainen, Anna K.; Forsback, Sarita J.; Tredwell, Matthew; Sandford, Graham; Moore, Peter R.; Huiban, Mickael; Luthra, Sajinder K.; Passchier, Jan; Solin, Olof; Gouverneur, Veronique Organic Letters, 2013 , vol. 15, # 11 p. 2648 - 2651]

Trifluoromethylation of aryl and heteroaryl halides with fluoroform-derived CuCF3: scope, limitations, and mechanistic features

[Lishchynskyi, Anton; Novikov, Maxim A.; Martin, Eddy; Escudero-Adan, Eduardo C.; Novak, Petr; Grushin, Vladimir V. Journal of Organic Chemistry, 2013 , vol. 78, # 22 p. 11126 - 11146]

Direct Synthesis of a Trifluoromethyl Copper Reagent from Trifluoromethyl Ketones: Application to Trifluoromethylation

[Serizawa, Hiroki; Aikawa, Kohsuke; Mikami, Koichi Chemistry - A European Journal, 2013 , vol. 19, # 52 p. 17692 - 17697]

Nucleophilic trifluoromethylation of aryl halides with methyl trifluoroacetate

[Langlois, Bernard R.; Roques, Nicolas Journal of Fluorine Chemistry, 2007 , vol. 128, # 10 p. 1318 - 1325]

More Articles...