Pivalase catalytic antibodies: towards abzymatic activation of prodrugs

…, MT Reymond, JL Reymond

Index: Bensel, Nicolas; Reymond, Martine T.; Reymond, Jean-Louis Chemistry - A European Journal, 2001 , vol. 7, # 21 p. 4604 - 4612

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Citation Number: 27

Abstract

Abstract Screening of monoclonal-antibody libraries generated against the tert-butyl phosphonate hapten 2 and the chloromethyl phosphonate hapten 3 with pivaloyloxymethyl- umbelliferone 1 as a fluorogenic substrate led to the isolation of eleven catalytic antibodies with rate accelerations around k cat/k uncat= 10 3. The antibodies are not inhibited by the product and accept different acyloxymethyl derivatives of acidic phenols as substrates. ...

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