ChemBioChem

Five??component cascade synthesis of nucleotide analogues in an engineered self??immobilized enzyme aggregate

RA Scism, BO Bachmann

Index: Scism, Robert A.; Bachmann, Brian O. ChemBioChem, 2010 , vol. 11, # 1 p. 67 - 70

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Citation Number: 23

Abstract

Nucleoside analogues are important agents in the battle against some of the most serious human illnesses including cancer, parasitic infections and viral diseases.[1–3] In combating viral infections such as HIV, herpes simplex virus, and hepatitis C, nucleoside analogues are particularly indispensable and target reverse transcriptases, polymerases or other enzymes involved in DNA/RNA synthesis, replication and repair.[4–6] Most nucleoside analogue ...