Hydrolysis of P 2-purinoceptor agonists by a purified ectonucleotidase from the bovine aorta, the ATP-diphosphohydrolase

…, J Sévigny, P D'Orléans-Juste, AR Beaudoin

Index: Picher; Sevigny; D'Orleans-Juste; Beaudoin Biochemical pharmacology, 1996 , vol. 51, # 11 p. 1453 - 1460

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Citation Number: 66

Abstract

Pharmacologists are becoming more and more aware of the possibility that certain ATP analogues currently used to classify the P2-purinoceptors are dephosphorylated by ectonucleotidases. In this study, we provide evidence that in the vascular system, these purine analogues are hydrolysed by an ATP-diphosphohydrolase (ATPDase). This enzyme is known as the major plasma membrane nucleotidase of endothelial and smooth muscle ...