Wittig reactions in water media employing stabilized ylides with aldehydes. Synthesis of α, β-unsaturated esters from mixing aldehydes, α-bromoesters, and Ph3P in …
A El-Batta, C Jiang, W Zhao, R Anness…
Index: Ramage, Robert; Griffiths, Gareth J.; Shutt, Fiona E.; Sweeney, John N. A. Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1984 , # 7 p. 1531 - 1537
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Citation Number: 139
Abstract
... J. Org. ... The scope of the aqueous Wittig reaction is extended to 24 examples of one-pot mixtures of Ph 3 P, α-bromoesters, and aldehydes in sodium bicarbonate solution (at 20 °C for 40 min to 3 h) to provide Wittig products of up to 99% yield and up to 98% E-selectivity. ...
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