One-pot reductive mono-N-alkylation of aromatic nitro compounds using nitriles as alkylating reagents

S Neogi, D Naskar

Index: Neogi, Subhasish; Naskar, Dinabandhu Synthetic Communications, 2011 , vol. 41, # 13 p. 1901 - 1915

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Abstract

Abstract A one-pot, simple, selective, and efficient protocol for the synthesis of aromatic secondary amines from various nitro arenes and nitriles in the presence of 10% Pd/C catalyst under H2 at atmospheric pressure and ambient temperature in tetrahydrofuran is illustrated. The scope and limitations of this method have been examined.