Synthesis of 2, 3, 6, 8-tetrasubstituted chromone scaffolds

…, EAA Wallén, M Grøtli, K Luthman

Index: Dahlen, Kristian; Wallen, Erik A. A.; Grotli, Morten; Luthman, Kristina Journal of Organic Chemistry, 2006 , vol. 71, # 18 p. 6863 - 6871

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Citation Number: 51

Abstract

A useful and efficient synthetic strategy to 2, 3, 6, 8-tetrasubstituted chromone derivatives has been developed. 2-Aryl/styryl-8-bromo-6-chloro-3-hydroxychromone derivatives were synthesized and used as scaffolds by introducing a variety of substituents in the 3-, 6-, and 8- positions using palladium-mediated reactions. Excellent regioselectivity in all positions could be obtained by performing reactions in the 8-position first, in which Stille, Heck, ...