Tetrahedron

General and efficient synthesis of 2, 3-unsubstituted indoles catalyzed by acidic mesoporous molecular sieves

N Sun, L Hong, F Huang, H Ren, W Mo, B Hu, Z Shen…

Index: Sun, Nan; Hong, Lingfen; Huang, Fang; Ren, Hong; Mo, Weimin; Hu, Baoxiang; Shen, Zhenlu; Hu, Xinquan Tetrahedron, 2013 , vol. 69, # 19 p. 3927 - 3933

Full Text: HTML

Citation Number: 5

Abstract

A general and efficient method for the synthesis of 2, 3-unsubstituted indoles has been established by the intramolecular cyclization of N-benzyl 2-anilinoacetals. Acidic mesoporous molecular sieve (MCM-41-SO3H) has shown excellent catalytic activity on this transformation, and the 2, 3-unsubstituted indoles bearing 7-substituent or strong electron- withdrawing substituents also could be achieved by this protocol. Moreover, the ...