Tetrahedron: Asymmetry

Synthesis and resolution of 1, 1-bi-8-methylisoquinoline: Formation of an optically active complex with high chiral recognition

G Chelucci, MA Cabras, A Saba, A Sechi

Index: Chelucci, Giorgio; Cabras, M. Antonietta; Saba, Antonio; Sechi, Alessandra Tetrahedron Asymmetry, 1996 , vol. 7, # 4 p. 1027 - 1032

Full Text: HTML

Citation Number: 36

Abstract

The synthesis and resolution of 1, 1-bi-8-methylisoquinoline (±)-5 is reported. An optically active palladium complex with high chiral recognition was formed during the complexation between a chiral palladium complex and the two enantiomers of (±)-5. The free energy barrier ΔG≠ for interconversion of enantiomers was estimated to be 97, 2 KJ/mol at 40° C.

Related Articles:

Synthesis and radioligand binding studies of C-5-and C-8-substituted 1-(3, 4-dimethoxybenzyl)-2, 2-dimethyl-1, 2, 3, 4-tetrahydroisoquinoliniums as SK channel …

[Journal of Medicinal Chemistry, , vol. 48, # 15 p. 4972 - 4982]

Preparation of Optically Active 8, 8'-Disubstituted 1, 1'-Biisoquinoline

[Heterocycles, , vol. 42, # 1 p. 415 - 422]

Synthesis of isoquinolines from indenes

[Journal of Organic Chemistry, , vol. 45, # 26 p. 5312 - 5315]

More Articles...