N-Nitrosobenzylmethylamine hydroxylation and coumarin 7-hydroxylation: catalysis by rat esophageal microsomes and cytochrome P450 2A3 and 2A6 enzymes

LB von Weymarn, ND Felicia, X Ding…

Index: Von Weymarn, Linda B.; Felicia, Nadia D.; Ding, Xinxin; Murphy, Sharon E. Chemical Research in Toxicology, 1999 , vol. 12, # 12 p. 1254 - 1261

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Citation Number: 32

Abstract

N-Nitrosobenzylmethylamine (NBzMA) is a potent and selective esophageal carcinogen in the rat and may be a causative agent for human esophageal cancer. This nitrosamine, like most, must be metabolically activated to exert its carcinogenic potential. NBzMA may be metabolized by P450-catalyzed methyl or methylene hydroxylation; the latter is believed to be the activation pathway. The sensitivity of the esophagus to NBzMA-induced ...

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