Organic letters

Reactions of Oxetan-3-tert-butylsulfinimine for the Preparation of Substituted 3-Aminooxetanes

PJ Hamzik, JD Brubaker

Index: Hamzik, Philip J.; Brubaker, Jason D. Organic Letters, 2010 , vol. 12, # 5 p. 1116 - 1119

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Citation Number: 29

Abstract

The oxetane ring is useful in drug discovery as a bioisostere for both the geminal dimethyl group and the carbonyl group. A convenient, straightforward approach to access structurally diverse 3-aminooxetanes through the reactivity of oxetan-3-tert-butylsulfinimine and the corresponding sulfinylaziridine is described.