Syntheses of hydroxyalkyl and mercaptoalkyl derivatives of sulfur-containing amino acids

A Zilkha, S Rappoport

Index: Zilkha,A.; Rappoport,S. Journal of Organic Chemistry, 1963 , vol. 28, p. 1105 - 1107

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Citation Number: 12

Abstract

Exclusive preparation of N-hydroxyalkyl derivatives of cysteine was accomplished by N- hydroxyalkylation of S-benzylcysteine, and then splitting off the benzyl protecting group by reaction with metallic sodium in liquid ammonia. These derivatives can also be obtained by reducing the doubly N-substituted cystine derivative.