… vivo evaluation of 3??[11C] methyl??(3??methoxy??naphthalen)??2??yl??(1??benzyl??piperidin)??4??yl??acetate (SB??235753), as a putative dopamine D4 receptors antagonist for …
M Matarrese, D Soloviev, RM Moresco…
Index: Matarrese; Soloviev; Moresco; Todde; Simonelli; Colombo; Magni; Carpinelli; Fazio; Kienle, M. Galli Journal of Labelled Compounds and Radiopharmaceuticals, 2000 , vol. 43, # 4 p. 359 - 374
Full Text: HTML
Citation Number: 12
Abstract
The precursor for the radiosynthesis 3-hydroxynaphthyl-2-[N-benzyl)-piperidyl]-acetate hydrochloride was prepared by a four-step synthesis starting from ethyl-4-pyridyl acetate. The radiolabelling consisted of methylation with [ 11 C]methyltriflate in dimethylformamide in the presence of potassium hydroxide. [ 11 C]SB-235753, was synthesised in 30 min with a radiochemical yield of 10±5% (EOS, non-decay corrected) with 99% radiochemical purity and specific radioactivity of ...
Related Articles:
[Peterson, Quinn P.; Hsu, Danny C.; Goode, David R.; Novotny, Chris J.; Totten, Ryan K.; Hergenrother, Paul J. Journal of Medicinal Chemistry, 2009 , vol. 52, # 18 p. 5721 - 5731]
[Gong, Leyi; Hogg, J. Heather; Collier, James; Wilhelm, Robert S.; Soderberg, Carol Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3597 - 3600]
[Gong, Leyi; Hogg, J. Heather; Collier, James; Wilhelm, Robert S.; Soderberg, Carol Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 20 p. 3597 - 3600]
[Gupta; Saxena; Jain; Anand Archiv der Pharmazie, 1984 , vol. 317, # 12 p. 1010 - 1017]