Synlett

An Unprecedented Coupling Reaction of Arylmagnesium Compounds with Tetrahydrofuran Providing 2-Aryltetrahydrofuran Mediated by an Iodoalkane-EtMgBr …

A Inoue, H Shinokubo, K Oshima

Index: Inoue, Atsushi; Shinokubo, Hiroshi; Oshima, Koichiro Synlett, 1999 , # 10 p. 1582 - 1584

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Citation Number: 17

Abstract

Abstract: An extremely facile coupling reaction between arylmagnesium compounds and THF by means of an iodoalkane–EtMgBr system provides 2-aryltetrahydrofurans. One-pot synthesis of 2-thienyltetrahydrofuran is achieved from thiophene and THF using this coupling reaction. Key words: coupling, iodine, magnesium, radical reactions, tetrahydrofuran

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