N??Arylhydroxamic Acids as Novel Oxidoreductase Substrates

…, K Krikstopaitis, R Lolck, P Schneider…

Index: Kulys, Juozas; Deussen, Heinz-Josef; Krikstopaitis, Kastis; Lolck, Rikke; Schneider, Palle; Ziemys, Arturas European Journal of Organic Chemistry, 2001 , # 18 p. 3475 - 3484

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Citation Number: 11

Abstract

Abstract N-Arylhydroxamic acids (AHAs) are promising novel N− OH mediators for oxidoreductase catalysis. They are electrochemically active compounds with a redox potential of 0.31− 0.41 V vs. SCE. Representative oxidoreductases, eg fungal peroxidase from Coprinus cinereus (rCiP), catalyze the oxidation of AHAs with apparent bimolecular constants (k ox) of 7.1· 10 3 to 1.5· 10 7 M− 1 s− 1 at pH= 8.5 and 25 C. The limiting step in ...

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