Ring-modified analogues and molecular dynamics studies to probe the requirements for fungicidal activities of malayamycin a and its N-nucleoside variants

O Loiseleur, D Ritson, M Nina, P Crowley…

Index: Loiseleur, Olivier; Ritson, Dougal; Nina, Mafalda; Crowley, Patrick; Wagner, Trixie; Hanessian, Stephen Journal of Organic Chemistry, 2007 , vol. 72, # 17 p. 6353 - 6363

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Citation Number: 19

Abstract

The importance of functional group orientations and the integrity of the bicyclic perhydrofuran core of malayamycin A and two equally active N-nucleoside analogues as fungicides were investigated. Two analogues 10 and 11, representing a THP-truncated and a bicyclic aza-variant, were synthesized and found to be inactive. Molecular dynamics studies on malayamycin A and analogues were performed to highlight the importance of ...

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