Chlorination/cyclodehydration of amino alcohols with SOCl2: an old reaction revisited

F Xu, B Simmons, RA Reamer, E Corley…

Index: Xu, Feng; Simmons, Bryon; Reamer, Robert A.; Corley, Edward; Murry, Jerry; Tschaen, David Journal of Organic Chemistry, 2008 , vol. 73, # 1 p. 312 - 315

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Citation Number: 44

Abstract

A simple, one-pot preparation of cyclic amines via efficient chlorination of amino alcohols with use of SOCl2 has been developed. This approach obviates the need for the classical N- protection/O-activation/cyclization/deprotection sequence commonly employed for this type of transformation. The reaction pathways and the general scope of this method have also been investigated.

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