Organic letters

Efficient, Stereodivergent Access to 3-Piperidinols by Traceless P (OEt) 3 Cyclodehydration

PH Huy, AMP Koskinen

Index: Huy, Peter H.; Koskinen, Ari M. P. Organic Letters, 2013 , vol. 15, # 20 p. 5178 - 5181

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Citation Number: 13

Abstract

A stereodivergent and highly diastereoselective (dr up to> 19: 1 for both isomers), step economic (5–6 steps), and scalable synthesis (up to 14 g) of cis-and trans-2-substituted 3- piperidinols, the core motif of numerous bioactive compounds, providing efficient access to

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