The Reductive Conversion of Some Cyclic and Acyclic vic??Epoxides to Alcohols by Means of Lithium Aluminium Hydride/Aluminium Trichloride

V Andrejević, M Bjelaković, MM Mihailović…

Index: Andrejevic, Vladimir; Bjelakovic, Mira; Mihailovic, Milan M.; Mihailovic, Mihailo Lj. Helvetica Chimica Acta, 1985 , vol. 68, p. 2030 - 2032

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Citation Number: 6

Abstract

Abstract Unsubstituted medium-ring 1, 2-epoxycycloalkanes and certain vic-epoxyalkanes are reduced to the corresponding alcohols very slowly when LiAlH 4 alone is used as reducing agent. However, the combination of LiAlH 4 and AlCl 3, in a 2: 1 molar ratio (with respect to 1 mol-equiv. of epoxide) used in refluxing Et 2 O, greatly enhances these reductions, rendering them of interest for practical purposes.