The Journal of Organic Chemistry

A selective method for oxygen deprotection in bistrimethylsilylated terminal alkynols

RA Bunce, DV Hertzler

Index: Bunce, Richard A.; Hertzler, Donald V. Journal of Organic Chemistry, 1986 , vol. 51, # 18 p. 3451 - 3453

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Citation Number: 12

Abstract

A selective method for oxygen deprotection of bistrimethylsilylated o-alkynols is described using sulfonic acid type exchange resins in ether solvent. The method offers the advantages of selectivity toward the silicon-oxygen bond, easier monitoring of the reaction and workup, and higher yields (> 75%). Comparisons are made between standard aqueous acid procedures and a series of resins.

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