Tetrahedron Letters

Total synthesis of slow reacting substances (SRS).“Leukotriene C-2”(11-trans-leukotriene C)(3) and leukotriene D (4)

EJ Corey, DA Clark, A Marfat, G Goto

Index: Corey, E. J.; Clark, David A.; Marfat, Anthony; Goto, Giichi Tetrahedron Letters, 1980 , vol. 21, p. 3143 - 3146

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Citation Number: 81

Abstract

Abstract Syntheses are described for the “slow reacting substances” 11-trans-leukotriene C (3)(previously known as leukotriene C-2) and leukotriene D (4), the cys-gly analog of leukotriene C (2). The synthesized leukotrienes 3 and 4 were instrumental in the assignment of structure to these members of the family of naturally occuring slow reacting substances which includes also 2.