Synthesis and hybridization studies of a 5-aminopentanoic acid nucleobase (APN) dimer

SF Donaldson, SC Bergmeier, JV Hines…

Index: Donaldson, Susan F.; Bergmeier, Stephen C.; Hines, Jennifer V.; Gerdeman, Melinda S. Nucleosides, Nucleotides and Nucleic Acids, 2002 , vol. 21, # 2 p. 111 - 123

Full Text: HTML

Citation Number: 3

Abstract

We have prepared a 5-aminopentanoic acid nucleobase (APN) dimer and investigated its hybridization capabilities to complementary DNA using both UV melting and NMR techniques. ... We have prepared a 5-aminopentanoic acid nucleobase (APN) dimer and investigated its hybridization capabilities to complementary DNA using both UV melting and NMR techniques. ... The principle of antisense/antigene inhibition of gene expression requires the binding of a ...