Design and Synthesis of Minimalist Terminal Alkyne??Containing Diazirine Photo??Crosslinkers and Their Incorporation into Kinase Inhibitors for Cell??and Tissue?? …

…, X Cheng, GYJ Chen, SK Sze, HM Shen…

Index: Li, Zhengqiu; Hao, Piliang; Li, Lin; Tan, Chelsea Y. J.; Cheng, Xiamin; Chen, Grace Y. J.; Sze, Siu Kwan; Shen, Han-Ming; Yao, Shao Q. Angewandte Chemie - International Edition, 2013 , vol. 52, # 33 p. 8551 - 8556 Angew. Chem., 2013 , vol. 125, # 33 p. 8713 - 8718,6

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Citation Number: 51

Abstract

Photoaffinity labeling (PAL) is a powerful technique in chemical biology and chemical proteomics, and has been successfully demonstrated on a variety of non-covalent molecular interactions.[1] Recently, we and others have shown that this approach is suitable for interrogating noncovalent protein–drug interactions under native cellular conditions.[2, 3] To do so, typically the drug is derivatized with a photo-reactive group and a reporter group ( ...